Difference Between Acute And Chronic Leukemia Pdf
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Leukemia , also spelled leukaemia , is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. The exact cause of leukemia is unknown. Treatment may involve some combination of chemotherapy , radiation therapy , targeted therapy , and bone marrow transplant , in addition to supportive care and palliative care as needed.
Leukaemia is the eleventh commonest UK cancer. The four main subtypes have different clinical profiles, particularly between chronic and acute types. To identify the symptom profiles of chronic and acute leukaemia in adults in primary care.
It starts when immature white blood cells called blasts become cancerous. These abnormal blast cells are known as leukaemia cells. They multiply quickly and continue to divide but never mature into normal cells.
Acute myeloid leukaemia (AML)
The Mario Lemieux Center for Blood Cancers offers personalized treatments for patients with all types of blood cancer. The Gumberg Family Resource Center provides educational resources for patients and caregivers. UPMC Hillman Cancer Center offers patients access to the latest advances in cancer prevention, detection, diagnosis, and treatment through cancer clinical trials. For general information or questions, call Leukemia is the result of the rapid overproduction of abnormal white blood cells.
Leukemia is classified by the type of white blood cells affected and by how quickly the disease progresses. Lymphocytic leukemia also known as lymphoid or lymphoblastic leukemia develops in the white blood cells called lymphocytes in the bone marrow. Myeloid also known as myelogenous leukemia may also start in white blood cells other than lymphocytes, as well as red blood cells and platelets. Acute leukemia is rapidly progressing and results in the accumulation of immature, functionless blood cells in the bone marrow. Chronic leukemia progresses more slowly and results in the accumulation of relatively mature, but still abnormal, white blood cells.
Types of leukemia
Patient information : See related handout on leukemia , written by the authors of this article. Leukemia is a clonal proliferation of hematopoietic stem cells in the bone marrow. The four broad subtypes most likely to be encountered by primary care physicians are acute lymphoblastic, acute myelogenous, chronic lymphocytic, and chronic myelogenous. Acute lymphoblastic leukemia occurs more often in children, whereas the other subtypes are more common in adults. Risk factors include a genetic predisposition as well as environmental factors, such as exposure to ionizing radiation. Symptoms are nonspecific and include fever, fatigue, weight loss, bone pain, bruising, or bleeding. A complete blood count usually reveals leukocytosis and other abnormally elevated or depressed cell lines.
What Is Chronic Myeloid Leukemia?
Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms related to cytopenias. Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis programmed cell death lead to replacement of normal blood elements with malignant cells.
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