p53 gene and cancer pdf

P53 Gene And Cancer Pdf

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The p53 gene TP53 is a gene that is mutated in many cancers, and is the most common gene mutation found in cancer cells. The gene is a type of tumor suppressor gene that codes for a protein that inhibits the development and growth of tumors.

PLoS Biol 2 2 : e This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Late-stage cancers are notoriously unresponsive to treatment, making certain hard-to-detect cancers particularly insidious.

The p53 tumor suppressor gene in breast cancer

Primary information of p53 gene. It had been hypothesized to exist before as the target of the SV40 virus, a strain that induced development of tumors. Although it was initially presumed to be an oncogene, its character as a tumor suppressor gene was revealed in In , p53 protein has been voted molecule of the year by the Science magazine. The p53 protein is a phosphoprotein made of amino acids. It consists of four units or domains :.

Mutant p53 as a guardian of the cancer cell

The majority of human cancers acquire mutations that abrogate the p53 tumor suppressor network and, as a consequence, p53 is one of the most extensively studied proteins in cancer research. Because of its potent tumor suppressive activity, it is widely assumed that a molecular understanding of p53 action will produce fundamental insights into natural processes that limit tumorigenesis and may identify key molecular targets for therapeutic intervention. Despite a significant body of literature detailing the biochemical and biological functions of p53, much remains to be elucidated. Indeed, the p53 network is as complex and enigmatic as it is relevant. It is the goal of this article, written 30 years after the discovery of p53, to present a concise review of the tumor suppressor role of the p53 network and to highlight the context-dependent nature of p53 target-gene functions. Hence, p53 can be activated in response to DNA damage, oncogene activation, or hypoxia, in which it subsequently orchestrates biological outputs such as apoptosis, cell-cycle arrest, senescence, or modulation of autophagy Yee and Vousden ; Riley et al. Importantly, these p53 tumor suppressor functions are context-dependent and may be influenced by numerous factors, including cell type, microenvironment, and oncogenic events acquired during the course of tumor evolution.

The p53 Gene and Its Role in Cancer

TP53, encoding p53, is one of the most famous tumor suppressor genes. The majority of human cancers demonstrate the inactivation of the p53 pathway. Mutant p53 not only, no longer, functions as a tumor suppressor but can also exert tumor-promoting effects.

Alterations of the p53 tumor suppressor gene are the most common genetic changes found so far in breast cancer, suggesting that the gene plays a central role in the development of the disease. A number of independent groups using different methods of detection have shown that p53 alterations are associated with more aggressive tumor biologic factors and a poorer prognosis in breast cancer patients. Because of its possible role in the regulation of apoptosis and response to DNA damage, p53 status could also be a predictive marker for response to hormonal or chemotherapy. This is a preview of subscription content, access via your institution. Rent this article via DeepDyve.

Among women, breast cancer is the leading cause of cancer-related mortality and the most common type of cancer worldwide 1 — 3. Breast cancer is the second most common cancer in the world, and its incidence is increasing, with a total of 1,, cases in compared to , in Breast cancer causes , annual deaths, representing It is the most prevalent cancer in the world today, with incidence rates highest in industrialized countries. While researchers are rigorously searching for the etiology of the disease, a more sensitive and early detection employing novel biomarkers is required for breast cancer patients.

Tumor Suppressive Functions of p53

Mutations in the p53 gene are one of the commonest specific genetic changes found in human cancer.

Recent Advances in p53 Research and Cancer Treatment

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cancer cells and the p53 protein and the p53 response to DNA damage represent key points for therapeutic intervention. The p53 tumour suppressor gene is.

The p53 tumor suppressor gene in breast cancer

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